Semaglutide for PCOS: What You Need to Know About This Treatment

When you have PCOS, polycystic ovary syndrome, a hormonal disorder affecting how ovaries work and often leading to weight gain, irregular periods, and insulin resistance. Also known as polycystic ovarian syndrome, it’s not just about fertility—it’s about metabolism, energy, and long-term health. Many women with PCOS struggle with weight, even when they eat well and exercise. That’s where semaglutide, a medication originally developed for type 2 diabetes that mimics a hormone called GLP-1 to slow digestion and reduce appetite. Also known as Ozempic or Wegovy, it’s now being used off-label for weight loss in PCOS patients. It doesn’t fix the root hormonal imbalance, but it helps the body respond better to insulin and cut cravings, which makes a big difference for those stuck in a cycle of weight gain and fatigue.

Insulin resistance is one of the biggest drivers of PCOS symptoms. When your body can’t use insulin properly, it stores more fat, especially around the belly, and your ovaries make too much testosterone. That’s why drugs like metformin, a common insulin-sensitizing drug used for decades in PCOS are still first-line treatments. But metformin doesn’t always lead to significant weight loss. Semaglutide does—studies show people with PCOS lose 10-15% of their body weight on average, which can restore periods, improve fertility, and lower diabetes risk. It’s not magic, though. You still need to eat well and move. But semaglutide takes the edge off hunger, making those changes possible.

Not everyone with PCOS needs semaglutide. It’s usually considered after lifestyle changes and metformin haven’t worked well enough. Side effects like nausea, constipation, or dizziness are common at first but often fade. It’s also expensive without insurance, and access can be tricky. Still, for women who’ve tried everything and still can’t lose weight, it’s becoming a game-changer. Below, you’ll find real-world advice on managing medications during travel, understanding drug interactions, reading labels correctly, and avoiding common mistakes with weight-related treatments. These aren’t just random posts—they’re the practical pieces you need to make semaglutide work safely and effectively if you’re considering it.