When working with Trazodone, a serotonin‑modulating antidepressant commonly prescribed for depression and insomnia. Also known as Desyrel, it helps balance mood and promote sleep without the strong dependence risk of classic hypnotics.
As an antidepressant, trazodone works by partially inhibiting serotonin reuptake while antagonizing certain serotonin receptors. This dual action means the drug trazodone can improve depressive symptoms and, at lower doses, act as a sedative. The relationship can be expressed as: Trazodone ↔ antidepressant → serotonin regulation.
When the goal shifts to treating insomnia, clinicians often start trazodone at 25–50 mg bedtime. Compared with benzodiazepines, it offers less rebound insomnia and lower abuse potential. The drug‑insomnia link forms a clear triple: Trazodone encompasses insomnia management and requires dose adjustment.
Typical dosing begins with 50 mg at night, then may be increased by 25 mg weekly to a target of 150–300 mg, depending on response and tolerance. Split‑dose regimens (e.g., 100 mg morning, 50 mg evening) can address both depressive and sleep symptoms. Proper titration minimizes side‑effects and aligns with the semantic rule that effective treatment requires gradual dosage escalation.
Common side effects include drowsiness, dry mouth, and orthostatic hypotension. Rarely, patients experience priapism—a prolonged erection that needs urgent care. As a side effect, priapism illustrates how adverse reactions influence treatment adherence and may prompt a switch to another antidepressant.
Trazodone can interact with other serotonergic agents such as SSRIs or MAO inhibitors, raising the risk of serotonin syndrome. Combining it with alcohol or strong CYP3A4 inhibitors (e.g., ketoconazole) can increase plasma levels and sedation. Understanding these interactions is key because drug‑interaction knowledge enables safer prescribing. Below you’ll find a curated set of articles that explore related medications, dosage strategies, safety tips, and real‑world comparisons to help you make informed decisions about trazodone and its place in your health plan.
A detailed 2025 guide comparing Trazodone with top alternatives, covering mechanisms, side effects, dosages, and how to choose the right sleep or depression medication.
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