Proton Pump Inhibitors and Antifungals: How They Interfere with Absorption and Effectiveness
- by Simon Bruce
- Dec, 10 2025
Proton pump inhibitors can drastically reduce the absorption of key antifungals like itraconazole and ketoconazole, leading to treatment failure. Fluconazole is unaffected by stomach pH but interacts with blood thinners. New research shows PPIs may also boost antifungal power-creating a complex clinical paradox.
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